nūhou

E like me ke kāʻei o ke ʻano o nā huahana kūlohelohe bioactive a me nā lāʻau lapaʻau (e like me ka laahi uʻi ʻaʻokeʻo dexamethadine), hiki ke loaʻa ka moralane mai ke kī kikowaena nui o ka papa o 1-benzyl octahydroisoquinoline e ʻekolu mau kaʻe o ka hopena kemika. asymmetric catalytic hydrogenation o ka hoʻololi ʻana o ka metal a me ka desematization o ka cyclohexamine oxidase a me ka boramine, akā ua loaʻa i kēia mau ala a nā palupalu e like me ka stereoselective maikaʻi, kumukūʻai kiʻekiʻe kiʻekiʻe, ʻilihua atomic maikaʻi ʻole a pehu kino kūlohelohe.

ʻO Tianjin institute o ka hana hoʻonaʻauao ʻenehana, ka noiʻi o Kina i ka ʻimi noiʻi ʻo Zhu Duiming, ʻo Wu Qia i alakaʻi i ka biocatalysis a me ka hui lāʻau kūlohelohe, e hoʻohana ana i ka Imine Reductase (Imine Reductase, IRED) i ka hoʻoneʻe ʻana me ka hoʻōki o ka alpha, beta unsaturated Imine (1 - benzyl ʻeono hydrogen isoquinoline derivatives), ka mākaukau kūleau o nā mea e pili ana - 1 benzyl ʻewalu hydrogen isoquinoline derivatives, no kēia papa o ka hoʻohui hāmeʻa e hāʻawi i kahi ala o ka catalysis biology.

agfd

Ma kēia noiʻi ʻana, hōʻike ʻia ka waihona imine reductase ma ke hoʻohana ʻana i ka substrate mua o ka dextromethorphan, a ua ʻike ʻia ʻelua o nā huina o ka huakaʻi e hōʻike i ka stereoselective kiʻekiʻe a me nā mea hoʻohui, me ka enantiomer throughput a hiki i ka 98% (S) a me>. ʻoi ka 5.4 × 10-2 a me 24.1 × 10-2 s-1 mm-1, kēlā me kēia.ʻO kēia kumu, ua hoʻokū ʻia kahi ʻano hoʻoliʻi lāʻau nui, a ua loaʻa ka hopena hoʻokaʻawale o ka huahana ma ka 74% a me 80%. Ma hope mai, ua loaʻa ka enzyme me ka hoʻoluʻu spatial kiʻekiʻe i ka hoʻomākaukau ʻana i nā kumuwaiwai e loaʻa ana i nā mea like ʻole i ka p-kūlana a me ka kūlana o ka hauna mua o nā pakanā, ka mea e hiki ai iā ia ke kiʻekiʻe nui a me ka hoʻokaʻawale ʻana i nā ʻāpana ʻewalu he nui, a ua loaʻa iā ia nā lanakila koikoi keu. ke ʻano o nā hanana synthes o kēia mau pūmū.

Kākoʻo ʻia ia noiʻi e ka ʻenehana kūlohelohe kūloko o Kina (21778072) a me ke kōmike ʻenehana a me nā ʻenekela tianjin (15PTCYSY00020 a me 15PTGCCX00060) .Ko ka mea noiʻi i paʻi ʻia ma ka puke nūpepa Advanced catalysis & catalysis, a ua koho ʻia ʻo ia ka Hot Topic o bicatalysis .Yao peiyuan, ka mea noiʻi kumu i ke kumu ʻoihana ʻohinjin i ka ʻenehana, a me xu zefei, he haumāna haumāna puka, he mau mea alakaʻi kumu o ka pepa.


Nā hola mālama: Mei-28-2020